聽Westminster Council has given permission subject to the signing of a Section 106 planning gain deal.
The scheme will create a mixed-use, retail-led development, with shops below and 18 private apartments above.
This second phase follows the success of the initial phase which delivered 149,000sqft of retail space, let to Primark for its flagship store.
Land Securities asset management director Tim Allibone said: 鈥淥ur development will create some of the most outstanding retail and residential accommodation available in one of London鈥檚 most famous shopping locations.鈥
Frogmore director of asset management Eric Roseman added: 鈥淭his second phase in our planned regeneration of the Oriana block is particularly satisfying and as the momentum gathers around our ground-breaking Primark scheme, Crossrail, Centre Point redevelopment and St Giles, we will see the eastern end of Oxford Street finally come of age.鈥
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