The Clatterbridge Cancer Centre, designed by BDP, will be built next to the Royal Liverpool Hospital.
Subject to final approvals, construction work is expected to begin in summer 2016 and take just over two years to complete.
Andrew Cannell, chief executive of The Clatterbridge Cancer Centre, said: 鈥淲e are delighted to be working with Laing O鈥橰ourke on the next phase of this very exciting development, subject to business case approvals.聽 Getting the design right will be one of the most important factors in its success and the input of our staff and patient representatives working with Laing O鈥橰ourke and the architects will be invaluable in this.聽 We are also committed to maximising the wider community benefits of a project of this scale.鈥
Laing O鈥橰ourke director Tom Higgins said: 鈥淭his is a very exciting project for us and the confidence The Clatterbridge Cancer Centre NHS Foundation Trust has in us is testament to our expertise in the health sector.聽 The immediate priority is to now work closely with the architects and Clatterbridge Cancer Centre staff as well as patient groups to finalise the project鈥檚 design.鈥
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